Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

Abolghasem Jouyban1, Mohammad Amin Abolghasemi Fakhree1, Ali Shayanfar2

1Tabriz University of Medical Sciences
2Kimia Research Institute

Abstract


N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.

J Pharm Pharm Sci, 13 (4): 524-535, 2010

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