Regulatory and Study Conditions for the Determination of Bioequivalence of Highly Variable Drugs

Authors

  • Laszlo Endrenyi University of Toronto
  • Laszlo Tothfalusi Semmelweis University

DOI:

https://doi.org/10.18433/J3ZW2C

Abstract

Purpose. The FDA Working Group on Highly Variable (HV) Drugs recently presented interim procedures and conditions for determining the bioequivalence (BE) of HV drug products. They included analysis by the method of scaled average BE (SABE), a switching coefficient of variation of CVS = 30% and a regulatory standardized variation of CV0 = 25% for applying SABE, and the use of a secondary regulatory criterion restricting to 0.80-1.25 the point estimate for the ratio of estimated geometric means (GMR) of the two formulations. These conditions are scrutinized in the present communication. Methods. 3-period BE studies were simulated with various statistical and regulatory assumptions. Power curves, obtained by gradually increasing the true GMR, compared performances of the methods of SABE, a constrained point estimate of GMR (PE/GMR), and the composite of these two approaches. The consumer risk of each procedure was evaluated. Results. With CV0 = 30% and PE/GMR = 0.80-1.25, the composite criterion of BE relied on the confidence limits of SABE. In contrast, with CV0 = 25% and/or PE/GMR = 0.87-1.15, the composite criterion approached almost completely the features of the GMR point estimate, especially at high within-subject variation. The consumer risk was near 5% with CV0 = 30% but much higher when CV0 = 25%. Conclusions. The condition of CVS = CV0 = 30% and PE/GMR = 0.80-1.25 is recommended as a composite regulatory criterion. With alternative settings of the conditions, such as the recommended CV0 = 25% and/or PE/GMR = 0.87-1.15, the composite criterion would reflect almost entirely the GMR point estimate. This would be an undesirable outcome.

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Author Biographies

Laszlo Endrenyi, University of Toronto

Department of Pharmacology Professor Emeritus

Laszlo Tothfalusi, Semmelweis University

Department of Pharmacodynamics Professor of Pharmacometrics

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Published

2009-05-20

How to Cite

Endrenyi, L., & Tothfalusi, L. (2009). Regulatory and Study Conditions for the Determination of Bioequivalence of Highly Variable Drugs. Journal of Pharmacy & Pharmaceutical Sciences, 12(1), 138–149. https://doi.org/10.18433/J3ZW2C

Issue

Section

Pharmaceutical Sciences; Review Articles