The Effect of Natural Health Products and Traditional Medicines on the Activity of Human Hepatic Microsomal-Mediated Metabolism of Oseltamivir

Authors

  • Rui Liu Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5,
  • Teresa W Tam Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5,
  • Jingqin Mao Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON, K1H 8M5,
  • Ammar Saleem Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON, K1H 8M5,
  • Anthony Krantis Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, K1H 8M5,
  • John T Arnason Centre for Research in Biopharmaceuticals and Biotechnology, University of Ottawa, Ottawa, ON, K1H 8M5,
  • Brian C Foster Therapeutic Products Directorate, Health Canada, Ottawa, ON, K1A 0K9,

DOI:

https://doi.org/10.18433/J3ZP42

Abstract

Purpose. Oseltamivir is a prodrug that requires metabolic activation but there is little information on whether natural health products interact to prevent the biotransformation by the carboxylesterase. Methods. HPLC-DAD-ESI-MSD and fluorometric assays were used to determine if 50-pooled mixed gender human liver microsomes can mediate the formation of the active carboxylate metabolite and then if this reaction is affected by natural health products. Results. Extracts from 6 traditional Cree botanicals, a commercially available Echinacea product, Goldenseal and a traditional Chinese medicine reduced the formation of the active drug. In addition to oseltamivir carboxylate we report the detection of two new metabolites which are derivatives of oseltamivir carboxylate, one of which is a metabonate formed as a result of methanol. Conclusions. In vitro studies would suggest that there is the potential for some natural health products used by patients in response to pandemic A/H1N1 to reduce drug efficacy. Further studies are required to determine if these potential interactions could be clinically significant.

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Published

2010-02-09

How to Cite

Liu, R., Tam, T. W., Mao, J., Saleem, A., Krantis, A., Arnason, J. T., & Foster, B. C. (2010). The Effect of Natural Health Products and Traditional Medicines on the Activity of Human Hepatic Microsomal-Mediated Metabolism of Oseltamivir. Journal of Pharmacy & Pharmaceutical Sciences, 13(1), 43–55. https://doi.org/10.18433/J3ZP42

Issue

Section

Pharmaceutical Sciences; Review Articles