Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System

Authors

  • Chengqun Chen School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Huijuan Zhang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Lin Hou School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Jinjin Shi School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Lei Wang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Chaofeng Zhang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Mingyue Zhang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Hongling Zhang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Xiufang Shi School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China
  • Huixiang Li Department of Pathology, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
  • Zhenzhong Zhang School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China

DOI:

https://doi.org/10.18433/J3H02C

Abstract

Purpose. The aim of this study was to prepare a new neovascularity targeting antitumor drug delivery system mediated by single-walled carbon nanotubes (SWNTs). Methods. In this study, antiangiogenesis agent 2-methoxyestradiol was loaded by SWNTs via π~π accumulation. The SWNTs were then linked with NGR (Asn-Gly-Arg) peptide, which could target tumor angiogenesis. This drug delivery system was characterized by transmission electron microscope, scanning electron microscopy, and atomic force microscope analysis. The suppression efficacy of tumor growth in cultured breast cancer cell line was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. The in vivo antitumor activity was evaluated on the Sarcoma (S180) tumor-bearing mice model. Results. The characteristics of this drug delivery system showed that the particle of complex was 190 ± 4.3 nm in size distribution and 23.56 ± 2.03 mV in zeta potential. The inhibition ratio of this SWNTs drug delivery system at 24, 48, and 72 h was about 57.7%, 83.6%, and 88.2%. Compared with normal saline group, the relative tumor volumes in the 2ME, SWNTs-2ME, and NGR-SWNTs-2ME groups were decreased 1 week after administration. Conclusion. This novel neovascularity targeting drug delivery system containing NGR-SWNTs-2ME may be beneficial to improve treatment efficacy and minimize side effects in future cancer therapy. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

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Published

2013-01-21

How to Cite

Chen, C., Zhang, H., Hou, L., Shi, J., Wang, L., Zhang, C., … Zhang, Z. (2013). Single-Walled Carbon Nanotubes Mediated Neovascularity Targeted Antitumor Drug Delivery System. Journal of Pharmacy & Pharmaceutical Sciences, 16(1), 40–51. https://doi.org/10.18433/J3H02C

Issue

Section

Pharmaceutical Sciences; Review Articles