Preparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates

Authors

  • Camila Braga Dornelas UFRJ
  • Alex Moura Silva UFRJ
  • Cide Brizio Dantas UFRJ
  • Carlos Rangel Rodrigues UFRJ
  • Sandra Solange Coutinho UFRJ
  • Plínio Cunha Sathler UFF
  • Helena Carla Castro UFF
  • Luiza Rosaria Sousa Dias UFF
  • Valeria Pereira Sousa UFRJ
  • Lúcio Mendes Cabral UFRJ

DOI:

https://doi.org/10.18433/J3HC72

Abstract

PURPOSE: This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. METHODS: By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposite obtained were evaluated to identify the interlamellar spacing values by XRD diffratograms. Tablets were prepared using methyldopa and theophylline as model drugs and the dissolution tests were carried out in simulated gastric fluid and simulated enteric fluid. RESULTS: AAM showed a good compactability and compressibility characteristics for tablets preparation. The intercalation yields (approximately 25%) of the nanocomposites were efficient. The AAM/PVP K-30 nanocomposites were successfully tested as dissolution enhancers and sustained release matrixes. CONCLUSIONS: The results also suggested the promising use of AAM (viscogel B8) and the new nanocomposite prepared by clay/PVP K-30 intercalation as a new matrix for sustained release and the feasibility of using these new nanocomposites as dissolution enhancer.

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Author Biographies

Camila Braga Dornelas, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil. 2. Instituto de Macromoléculas Professora Eloisa Mano (IMA), UFRJ, Rio de Janeiro, RJ, Brazil.

Alex Moura Silva, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

Cide Brizio Dantas, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

Carlos Rangel Rodrigues, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

Sandra Solange Coutinho, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

Plínio Cunha Sathler, UFF

3. LABioMol, Instituto de Biologia, UFF, Niterói, RJ, Brazil

Helena Carla Castro, UFF

3. LABioMol, Instituto de Biologia, UFF, Niterói, RJ, Brazil

Luiza Rosaria Sousa Dias, UFF

4. LQMed, Departamento de Tecnologia Farmacêutica, Faculdade de Farmácia, UFF, Niterói, RJ, Brazil.

Valeria Pereira Sousa, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

Lúcio Mendes Cabral, UFRJ

1. Departamento de Medicamentos, Faculdade de Farmácia, UFRJ, Rio de Janeiro, RJ, Brazil.

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Published

2011-01-21

How to Cite

Dornelas, C. B., Silva, A. M., Dantas, C. B., Rodrigues, C. R., Coutinho, S. S., Sathler, P. C., … Cabral, L. M. (2011). Preparation and Evaluation of a New Nano Pharmaceutical Excipients and drug Delivery System Based in Polyvinylpyrrolidone and Silicates. Journal of Pharmacy & Pharmaceutical Sciences, 14(1), 17–35. https://doi.org/10.18433/J3HC72

Issue

Section

Pharmaceutical Sciences; Review Articles