Sub-Maximal Exercise Altered the Prednisolone Absorption Pattern.

Authors

  • Kuei-Yu Chien Kainan University
  • Ting-Ting Chen National Taiwan Sport University
  • Jia Hsu National Taiwan Sport University
  • Ryh-Nan Pan Taiwan Police College
  • Jih-Heng Li Kaohsiung Medical University
  • Chia-Hua Kuo Taipei Physical Education College
  • Mei-Chich Hsu National Taiwan Sport University

DOI:

https://doi.org/10.18433/J3KG6B

Abstract

PURPOSE: Prednisolone has been widely used due to its relatively short pituitary inhibition and its moderate potency. Exercise is one of the non-pharmacological interventions for glucocorticoid- induced osteoporosis prevention. However, the effects of exercise on the pharmacokinetics of prednisolone were unclear. The purpose of this study was to evaluate the effects of sub-maximal exercise on the pharmacokinetics of prednisolone. METHODS: A randomized, double-blind, cross-over experimental design was used. Subjects needed to undertake two trials: a non-exercise trial (NE) and an exercise trial (E). After the first blood sampling, the subjects consumed 5mg of prednisolone with 100mL of water and then took a rest for 30 min. In the E trial, subjects cycled at 70% VO2max intensity until exhaustion. When subjects underwent the NE trial, they remained seated for the duration of the experiment. Serial blood samples were collected at 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 3, 4, 5, 6, 8, 10 and 12h after prednisolone administration. Prednisolone and cortisol concentration were analyzed with a validated high performance liquid chromatographic method. RESULTS: This study indicated that the maximum concentration of the E trial was significantly lower than the NE trial (p<0.05). However, the area under the serum concentration-time, the time to half life concentration, the time-averaged total body clearance, and the apparent volume of the distribution showed no significant difference between two trials. The mean of cortisol concentration in E trail increased 8 ±8.5 %. CONCLUSION: The results suggested that sub-maximal exercise altered the prednisolone absorption pattern.

Downloads

Download data is not yet available.

Author Biographies

Kuei-Yu Chien, Kainan University

Department of Geriatric Health Promotion

Ting-Ting Chen, National Taiwan Sport University

Graduate Institute of Coaching Sciences

Jia Hsu, National Taiwan Sport University

Graduate Institute of Sports Science

Ryh-Nan Pan, Taiwan Police College

Department of Disaster Management

Jih-Heng Li, Kaohsiung Medical University

Dean College of Pharmacy

Chia-Hua Kuo, Taipei Physical Education College

Laboratory of Exercise Biochemistry

Mei-Chich Hsu, National Taiwan Sport University

Graduate Institute of Sports Science

Downloads

Published

2010-04-08

How to Cite

Chien, K.-Y., Chen, T.-T., Hsu, J., Pan, R.-N., Li, J.-H., Kuo, C.-H., & Hsu, M.-C. (2010). Sub-Maximal Exercise Altered the Prednisolone Absorption Pattern. Journal of Pharmacy & Pharmaceutical Sciences, 13(1), 58–66. https://doi.org/10.18433/J3KG6B

Issue

Section

Pharmaceutical Sciences; Review Articles