Applications of β-limit Dextrin as a Matrix Forming Excipient for Fast Disintegrating Buccal Dosage Formats

Xin Qi1, Richard Tester2, Yu Liu2, Margaret Mullin3

1Glycologic Limited, 70 Cowcaddens Road, Glasgow, UK.
2Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, UK.
3School of Life Sciences, Glasgow University, Glasgow, UK.

Abstract


ABSTRACT - Purpose. To compare the properties of buccal delivery matrices (wafers) made with dextrin, β-limit dextrin and pre-gelatinised starch. Methods. The constituent α-glucans were tested for their mucoadhesive properties in solution plus their content of crystalline material (differential scanning calorimetry, DSC). Wafers were made by lyophilisation of aqueous solutions/dispersions of the α-glucans. Physical properties of the wafers were evaluated using texture analysis, dissolution coupled to photography and scanning electron microscopy (SEM). Results. The results highlighted how the β-limit dextrins chemical and physical properties were ideally suited for the production of buccal delivery wafers. Dissolution testing confirmed the excellent hydration profile of the β-limit dextrin (within wafers) with time. Using SEM it was evident that the homogeneous “bee-hive” like structure of the β-limit dextrin wafers, unlike the other α-glucans, provided a rapidly hydratable strong porous matrix. Conclusions. The β-limit dextrin α-glucan makes a superb (lyophilised) mucoadhesive delivery structure for the delivery of active agents to the buccal mucosa.

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J Pharm Pharm Sci, 15 (5): 669-679, 2012

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